This course covers algorithmic and computational tools for solving optimization problems with the goal of providing decision-support for business intelligence. We will cover the fundamentals of linear, integer and nonlinear optimization. We will emphasize optimization as a large-scale computational tool, and show how to link programming languages, such as Python, Java and C++, with optimization software, such as Gurobi and CPLEX, to develop industrial-strength decision-support systems. We will demonstrate how to incorporate uncertainty into optimization problems. Throughout the course, we will cover a variety of modern applications and show how to deploy large-scale optimization models.